Queen Hazima, wife of King Faisal I (1918-1920)

Zahra al-Yusuf, wife of President Mohammad Ali al-Abed (1932-1936)

Ward Shan al-Atasi, wife of President Hashem al-Atasi (1936-1939)

Mrs. Taj al-Din al-Hasani (1941-1943)

Bahira al-Dalati, wife of President Shukri al-Quwatli (1943-1949)

Noran al-Zaim, wife of President Husni al-Zaim (March-August 1949)

President Hashem al-Atasi returned to office in 1949-1951 and then again in 1954-1955 after the passing of his wife, making him the only Syrian widower president.

Mrs. Fawzi Selu (1951-1954)

Fatina al-Fanari, wife of President Adib al-Shishakli (1953-1954)

Tahiya Kazem, wife of President Gamal Abdul Nasser (1958-1961)

Mrs. Nazem al-Qudsi

Rabi'a al-Hussami, wife of President Louai al-Atasi

Mrs. Amin al-Hafez

Sahar Hasibi, wife of President Nur al-Din al-Atasi (1966-1970)

Mrs. Ahmad al-Khatib

Anissa Makhlouf, wife of President Hafez al-Assad (1970-2000)

Asma al-Assad, wife of President Bashar al-Assad (2000-present)